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      Cyclen
      
											
        
												
      • Product Name: Cyclen
        • 
												
      • CAS: 294-90-6
        • 
												
      • Purity: 
        • 
												
      • Appearance: off- white to slightly yellow crystalline  powder
        • 
												
      • 
											
      
											
      
												
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      Factory Supply industrial standard Cyclen 294-90-6 In Stock
      
        
      
        
        
             
      • Molecular Formula:C8H20N4
        • 
             
      • Molecular Weight:172.274
        • 
            
                                
      • Appearance/Colour:off- white to slightly yellow crystalline  powder 
        • 
                                
                                
      • Vapor Pressure:0.00309mmHg at 25°C 
        • 
                                
                                
      • Melting Point:108-113 °C 
        • 
                                
                                
      • Refractive Index:1.5872 (estimate) 
        • 
                                
                                
      • Boiling Point:283.8 °C at 760 mmHg 
        • 
                                
                                
      • PKA:10.53±0.20(Predicted) 
        • 
                                
                                
      • Flash Point:129.5 °C 
        • 
                                
                                
      • PSA：48.12000 
        • 
                                
                                
      • Density:0.874 g/cm3 
        • 
                                
                                
      • LogP:-0.32640 
        • 
                                
                               
        
      

    
      
    
    
      
        
      
            
      Cyclen(Cas 294-90-6) Usage
      
        
      
        
      
        	
                
                        
      
                         
                            
      Synthesis Reference(s)
      
                                  		
             			
      Journal of the American Chemical Society, 96, p. 2268, 1974 DOI: 10.1021/ja00814a056
      		
             		
      
                
                        
      
                         
                            
      Flammability and Explosibility
      
                                  		
             			
      Notclassified
      		
             		
      
                
                        
      
                         
                            
      General Description
      
                                  		
             			
      Cyclen is a microcyclic tetramine that can be used as a ligand that forms a co-ordination linkage with the surface metal cations. It can be used as a synthetic precursor. It can be prepared by S-alkylation of dithiooxamide with an excess amount of bromoethane.
      		
             		
      
                
                     
                   
        
      





         
        
      InChI:InChI=1/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2/p+4
                              
    
      
    
    
      
        
      
            
      294-90-6 Relevant articles
      
        
      
        
      
            
                       
      
                            
      Preparation and animal biodistribution of 166Ho labeled DOTA for possible use in intravascular radiation therapy (IVRT)
      
                            
      Das, Tapas,Chakraborty, Sudipta,Banerjeel, Sharmila,Samuel, Grace,Sarma,Venkatesh, Meera,Pillai
      
                            
      , p. 197 - 209 (2003)
      
                            
      
                                Owing to its favorable decay characteris...
                            
      
                        
      
                     
                       
      
                            
      A copper-cyclen coordination complex associated with a polyoxometalate anion: Synthesis, crystal structure and electrochemistry of [Cu(cyclen)(MeCN)] [W6O19]
      
                            
      Sarma, Monima,Chatterjee, Tanmay,Das, Samar K.
      
                            
      , p. 1114 - 1117 (2010)
      
                            
      
                                The reaction between Cu(NO3)2?3H2O and a...
                            
      
                        
      
                     
                       
      
                            
      Isomerization kinetics of lanthanide(III) complexes with the pendant-arm macrocyclic ligand 1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane
      
                            
      Pittet, Pierre-Andre,Frueh, Dominique,Tissieres, Veronique,Buenzli, Jean-Claude G.
      
                            
      , p. 895 - 900 (1997)
      
                            
      
                                The 13C and 1H NMR spectra of the comple...
                            
      
                        
      
                     
                       
      
                            
      A new synthesis of cyclen (1,4,7,10-tetraazacyclododecane)
      
                            
      Weisman, Gary R.,Reed, David P.
      
                            
      , p. 5186 - 5187 (1996)
      
                            
      
                                -
                            
      
                        
      
                     
                       
      
                            
      -
      
                            
      Kossai,R. et al.
      
                            
      , p. 1059 - 1062 (1979)
      
                            
      
                                -
                            
      
                        
      
                     
                       
      
                            
      A practical synthesis of 1,4,7,10-tetraazacyclododecane, a pivotal precursor for MRI contrast agents
      
                            
      Ferrari, Marinella,Giovenzana, Giovanni B.,Palmisano, Giovanni,Sisti, Massimo
      
                            
      , p. 15 - 21 (2000)
      
                            
      
                                A practical preparation of the versatile...
                            
      
                        
      
                     
                       
      
                            
      A microcalorimetric determination of the enthalpies of formation in solution of nickel(II) complexes with tetraaza macrocyclic ligands of varying size
      
                            
      Fabbrizzi, Luigi,Micheloni, Mauro,Paoletti, Piero
      
                            
      , p. 535 - 538 (1980)
      
                            
      
                                The enthalpies of formation of nickel co...
                            
      
                        
      
                     
                       
      
                            
      A new, facile synthesis of 1,4,7,10-tetraazacyclododecane: Cyclen
      
                            
      Athey, Phillip S.,Kiefer, Garry E.
      
                            
      , p. 4081 - 4085 (2002)
      
                            
      
                                This report outlines a new and efficient...
                            
      
                        
      
                     
                       
      
                            
      DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX
      
                            
      -
      
                            
      Paragraph 0058-0059,  (2021/03/19)
      
                            
      
                                To provide a metal complex that has high...
                            
      
                        
      
                     
                       
      
                            
      Preparation method of cyclen and intermediate thereof
      
                            
      -
      
                            
      ,  (2021/07/08)
      
                            
      
                                The invention discloses a preparation me...
                            
      
                        
      
                     
                       
      
                            
      Preparation method of cyclen
      
                            
      -
      
                            
      Paragraph 0061; 0062; 0063,  (2020/02/14)
      
                            
      
                                The invention provides a preparation met...
                            
      
                        
      
                     
                       
      
                            
      Preparation method of cycleanine
      
                            
      -
      
                            
      Paragraph 0031-0050,  (2020/02/10)
      
                            
      
                                The invention provides a preparation met...
                            
      
                        
      
                     
        
      
    
      
    
    
      
        
      
            
      294-90-6 Process route
      
        
      

                    
                    
      
                        
      
                            
                            
      
                                
                                
      
                                    
      
                                        
      
                                            
                                            C<sub>14</sub>H<sub>24</sub>N<sub>4</sub>
                                            
                                        
      
                                    
      
                                    
      
                                        
                                        
      C14H24N4 
      
                                    
      
                                
      

                            
      
                            
                            
      
                                
                                
      
                                    
                                
      
                                
                                
      
                                    
      
                                        
      
                                            
                                            cyclohexane-1,2-dione
                                            
                                        
      
                                    
      
                                    
      
                                        765-87-7
                                        
      cyclohexane-1,2-dione 
      
                                    
      
                                
      

                            
      
                            
                            
      
                                
                                
      
                                    
                                
      
                                
                                
      
                                    
      
                                        
      
                                            
                                            1,4,7,10-tetraazacyclododecan
                                            
                                        
      
                                    
      
                                    
      
                                        294-90-6
                                        
      1,4,7,10-tetraazacyclododecan 
      
                                    
      
                                
      

                            
      
                            
                        
      
                        
                        
      
                            Conditions
                            
      
                                
      
                                    Conditions
                                    Yield
                                
      
                                
                                
      
                                    
                                        
                                        
      

                                            
                                                

                                            
                                            With 
                                            
                                            
                                                
                                                    hydrogenchloride; 
                                            
                                            
                                                
                                            
                                            In 

                                            
                                                water; 
                                            
                                            
                                            
                                                
                                                            at 60 ℃;
                                                            
                                                            for 6h;
                                                            
                                            
                                        
      
                                        
                                          		
                                    
                                        

                                    
                                
      
                                
                            
      
                        
      
                        
                    
      
                    
                    
      
                        
      
                            
                            
      
                                
                                
      
                                    
      
                                        
      
                                            
                                            1,4,7,10-tetraazacyclododecane tetrahydrochloride
                                            
                                        
      
                                    
      
                                    
      
                                        10045-25-7
                                        
      1,4,7,10-tetraazacyclododecane tetrahydrochloride 
      
                                    
      
                                
      

                            
      
                            
                            
      
                                
                                
      
                                    
                                
      
                                
                                
      
                                    
      
                                        
      
                                            
                                            1,4,7,10-tetraazacyclododecan
                                            
                                        
      
                                    
      
                                    
      
                                        294-90-6
                                        
      1,4,7,10-tetraazacyclododecan 
      
                                    
      
                                
      

                            
      
                            
                        
      
                        
                        
      
                            Conditions
                            
      
                                
      
                                    Conditions
                                    Yield
                                
      
                                
                                
      
                                    
                                        
                                        
      

                                            
                                                

                                            
                                            With 
                                            
                                            
                                                
                                                    hydrogenchloride; 
                                            
                                            
                                                
                                            
                                            
                                                
                                            
                                        
      
                                        
                                          		
                                    
                                        95%
      
                                        

                                          		
                                
      
                                
                                
      
                                    
                                        
                                        
      

                                            
                                                

                                            
                                            With 
                                            
                                            
                                                
                                                    potassium hydroxide; 
                                            
                                            
                                                
                                            
                                            In 

                                            
                                                water; 
                                            
                                            
                                            
                                                
                                                            at 0 - 10 ℃;
                                                            
                                            
                                        
      
                                        
                                          		
                                    
                                        91.3%
      
                                        

                                          		
                                
      
                                
                                
      
                                    
                                        
                                        
      

                                            
                                                

                                            
                                            With 
                                            
                                            
                                                
                                                    potassium hydroxide; 
                                            
                                            
                                                
                                            
                                            
                                                
                                            
                                        
      
                                        
                                          		
                                    
                                        

                                    
                                
      
                                
                                
      
                                    
                                        
                                        
      

                                            
                                                

                                            
                                            With 
                                            
                                            
                                                
                                                    sodium hydroxide; 
                                            
                                            
                                                
                                            
                                            In 

                                            
                                                toluene; 
                                            
                                            
                                            
                                                
                                                            at 40 ℃;
                                                            
                                                            for 1h;
                                                            
                                                Reflux;
                                                            
                                            
                                        
      
                                        
                                          		
                                    
                                        13.77 g
      
                                        

                                          		
                                
      
                                
                                
      
                                    
                                        
                                        
      

                                            
                                                

                                            
                                            With 
                                            
                                            
                                                
                                                    sodium hydroxide; 
                                            
                                            
                                                
                                            
                                            In 

                                            
                                                water; toluene; 
                                            
                                            
                                            
                                                
                                            
                                        
      
                                        
                                          		
                                    
                                        12 g
      
                                        

                                          		
                                
      
                                
                            
      
                        
      
                        
                    
      
                    
               
    
      
     
    
      

        
        
      
            
      294-90-6 Upstream products
      
        
      
                    
        
                        
                        
      • 
                           
                                
        
                                    10045-25-7
                                
        
                                10045-25-7
                                
        
                                    1,4,7,10-tetraazacyclododecane tetrahydrochloride
                                
        
                          
                        
        • 
                        
                        
      • 
                           
                                
        
                                    137145-78-9
                                
        
                                137145-78-9
                                
        
                                    7-<2-(1,3-Dioxolan-2-yl)ethyl>-1,4,7,10-tetraazacyclododecane-1-carbaldehyde
                                
        
                          
                        
        • 
                        
                        
      • 
                           
                                
        
                                    52667-88-6
                                
        
                                52667-88-6
                                
        
                                    cyclen tetratosylate
                                
        
                          
                        
        • 
                        
                        
      • 
                           
                                
        
                                    368864-09-9
                                
        
                                368864-09-9
                                
        
                                    cis-octahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene-3,4-dione
                                
        
                          
                        
        • 
                        
                    
      
                    
        
      
            
      294-90-6 Downstream products
      
        
      
                    
        
                        
                        
      • 
                            
                                
        
                                    112193-83-6
                                
        
                                112193-83-6
                                
        
                                    1-benzyl-1,4,7,10-tetraazacyclododecane
                                
        
                            
                        
        • 
                        
                        
      • 
                            
                                
        
                                    67705-42-4
                                
        
                                67705-42-4
                                
        
                                    1,4,7,10-tetrazatricyclo[5.5.1.0]tridecane
                                
        
                            
                        
        • 
                        
                        
      • 
                            
                                
        
                                    114873-37-9
                                
        
                                114873-37-9
                                
        
                                    1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
                                
        
                            
                        
        • 
                        
                        
      • 
                            
                                
        
                                    138884-09-0
                                
        
                                138884-09-0
                                
        
                                    1,4,7-tribenzyl 1,4,7,10-tetraazacyclododecane 1,4,7-tricarboxylate
                                
        
                            
                        
        • 
                        
                    
      
                    
    
      
    

      
							
      
							
							
      
								
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