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2-Carboxybenzaldehyde

Product Name: 2-Carboxybenzaldehyde
CAS: 119-67-5
Purity:
Appearance: white crystal powder

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Product Details

Reliable factory customized supply 2-Carboxybenzaldehyde 119-67-5

Molecular Formula:C8H6O3
Molecular Weight:150.134
Appearance/Colour:white crystal powder
Vapor Pressure:0.00012mmHg at 25°C
Melting Point:94-96 °C(lit.)
Refractive Index:1.4500 (estimate)
Boiling Point:321.8 °C at 760 mmHg
PKA:4.57±0.10(Predicted)
Flash Point:162.6 °C
PSA：54.37000
Density:1,404 g/cm³
LogP:1.19730

2-Carboxybenzaldehyde(Cas 119-67-5) Usage

Synthesis Reference(s)	Tetrahedron Letters, 14, p. 3535, 1973 DOI: 10.1016/S0040-4039(01)86963-XThe Journal of Organic Chemistry, 32, p. 3200, 1967 DOI: 10.1021/jo01285a061
General Description	2-Carboxybenzaldehyde (also known as 2-formylbenzoic acid) serves as a key reactant in the Ugi four-component condensation (Ugi-4CC) to form stable primary adducts, which can be further transformed into isocoumarins. Its reactivity with phenacylamine dimethyl acetal and isocyanides under controlled conditions allows for the isolation and characterization of intermediates, demonstrating its utility in synthetic routes toward biologically relevant heterocycles. The compound's stability in solid state and tendency to rearrange in solution highlight its role in facilitating efficient and tunable chemical transformations.
Definition	ChEBI: An aldehydic acid which consists of benzoic acid substituted by a formyl group at position 2.

InChI:InChI=1/C8H6O3/c9-5-6-3-1-2-4-7(6)8(10)11/h1-5H,(H,10,11)/p-1

119-67-5 Relevant articles

Synthetic application of lithiation reactions. IX. A simplified synthesis of isocoumarin

Narasimhan,Mali

, p. 797 - 797 (1975)

-

Sturrock,M.G. et al.

, p. 3047 - 3051 (1971)

-

Matsuura et al.

, p. 6149,6154 (1968)

Prevention of manganese precipitation during the continuous selective partial oxidation of methyl aromatics with molecular oxygen in supercritical water

Fraga-Dubreuil, Joan,Garcia-Verdugo, Eduardo,Hamley, Paul A.,Perez, Eduardo,Pearson, Ian,Thomas, W. Barry,Housley, Duncan,Partenheimer, Walt,Poliakoff, Martyn

, p. 1866 - 1876 (2009)

Presented here is an investigation of th...

-

Cava et al.

, p. 2947 (1964)

-

Cava et al.

, p. 2076,2079 (1963)

-

Sidgwick,Clayton

, p. 2263 Anm. (1922)

-

Cava,Napier

, p. 3606 (1957)

-

Dahlgren,Schell

, p. 3200 (1967)

Selectivity in catalytic diol electrooxidation using a polypyridine ru(iv) complex

Navarro, Marcelo,De Giovani, Wagner F.,Romero, Jose R.

, p. 851 - 857 (1991)

1,2-, 1,3-, and 1,4-Butanediols and phth...

-

Maekawa,Sumimoto

, p. 941,942 (1960)

Facile construction of pyrrolo[1,2-: B] isoquinolin-10(5 H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors

Wu, Shanchao,Liu, Na,Dong, Guoqiang,Ma, Lin,Wang, Shengzheng,Shi, Wencai,Fang, Kun,Chen, Shuqiang,Li, Jian,Zhang, Wannian,Sheng, Chunquan,Wang, Wei

, p. 9593 - 9596 (2016)

An efficient redox-amination-aromatizati...

Oxidation of benzyl alcohol by pyridinium dichromate in acetonitrile. Using the paralmeta ratio of substituent effects for mechanism elucidation

Kabilan,Girija,Reis, Joao Carlos R.,Segurado, Manuel A.P.,De Oliveira, Jaime D. Gomes

, p. 1151 - 1157 (2002)

Rate constants were measured for the oxi...

Industrial synthesis method of o-aldehyde phenyl fatty acid

-

Paragraph 0074; 0076; 0077; 0083; 0085; 0086; 0088; 0090, (2020/01/08)

The invention provides an industrial syn...

Synthesis method of O-formyl benzoic acid

-

Paragraph 0009 0011-0012, (2019/12/25)

The invention discloses a synthesis meth...

Synthesis of chiral isoindolinones via asymmetric propargylation/lactamization cascade

Meng, Jiao-Long,Jiao, Tang-Qian,Chen, Ya-Heng,Fu, Rui,Zhang, Shu-Sheng,Zhao, Qian,Feng, Chen-Guo,Lin, Guo-Qiang

supporting information, p. 1564 - 1567 (2018/03/23)

A Zn-mediated propargylation/lactamizati...

119-67-5 Process route

: 95-47-6
o-xylene

: 118-90-1
ortho-methylbenzoic acid

: 612-20-4
2-(hydroxymethyl)benzoic acid

: 88-99-3,73607-73-5
benzene-1,2-dicarboxylic acid

: 119-67-5
o-carboxybenzaldehyde

Conditions

Conditions	Yield
o-xylene; With N-hydroxyphthalimide; air; cobalt(II) acetate; manganese(II) acetate; In acetic acid; at 150 ℃; for 3h; under 22801.5 Torr; With sodium hydroxide; at 90 ℃; Further stages.;	73% 6% 8% 3%

: 95-47-6
o-xylene

: 118-90-1
ortho-methylbenzoic acid

: 124-38-9,18923-20-1
carbon dioxide

: 612-20-4
2-(hydroxymethyl)benzoic acid

: 88-99-3,73607-73-5
benzene-1,2-dicarboxylic acid

: 65-85-0,8013-63-6
benzoic acid

: 119-67-5
o-carboxybenzaldehyde

Conditions

Conditions	Yield
With water; hydrogen bromide; dihydrogen peroxide; at 380 ℃; under 172517 Torr;	58.6 mol % 15.2 mol %

119-67-5 Upstream products

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612-40-8
2-carboxycinnamic acid
528-46-1
phthalonic acid
64148-19-2
2-dichloromethyl-benzonitrile

119-67-5 Downstream products

4195-21-5
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108902-34-7
2-(3-oxo-5,6-dihydro-imidazo[2,1-b]thiazol-2-ylidenemethyl)-benzoic acid
6936-87-4
3-(1H-indol-3-yl)isobenzofuran-1(3H)-one
73973-01-0
2-Methyl-3-phthalidyl-indol

Organic Intermediates: Pharmaceutical Intermediates

Product classification

Related products

2-Carboxybenzaldehyde

Reliable factory customized supply 2-Carboxybenzaldehyde 119-67-5

2-Carboxybenzaldehyde(Cas 119-67-5) Usage

119-67-5 Relevant articles

Synthetic application of lithiation reactions. IX. A simplified synthesis of isocoumarin

Narasimhan,Mali

, p. 797 - 797 (1975)

-

Sturrock,M.G. et al.

, p. 3047 - 3051 (1971)

-

Matsuura et al.

, p. 6149,6154 (1968)

Prevention of manganese precipitation during the continuous selective partial oxidation of methyl aromatics with molecular oxygen in supercritical water

Fraga-Dubreuil, Joan,Garcia-Verdugo, Eduardo,Hamley, Paul A.,Perez, Eduardo,Pearson, Ian,Thomas, W. Barry,Housley, Duncan,Partenheimer, Walt,Poliakoff, Martyn

, p. 1866 - 1876 (2009)

-

Cava et al.

, p. 2947 (1964)

-

Cava et al.

, p. 2076,2079 (1963)

-

Sidgwick,Clayton

, p. 2263 Anm. (1922)

-

Cava,Napier

, p. 3606 (1957)

-

Dahlgren,Schell

, p. 3200 (1967)

Selectivity in catalytic diol electrooxidation using a polypyridine ru(iv) complex

Navarro, Marcelo,De Giovani, Wagner F.,Romero, Jose R.

, p. 851 - 857 (1991)

-

Maekawa,Sumimoto

, p. 941,942 (1960)

Facile construction of pyrrolo[1,2-: B] isoquinolin-10(5 H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors

Wu, Shanchao,Liu, Na,Dong, Guoqiang,Ma, Lin,Wang, Shengzheng,Shi, Wencai,Fang, Kun,Chen, Shuqiang,Li, Jian,Zhang, Wannian,Sheng, Chunquan,Wang, Wei

, p. 9593 - 9596 (2016)

Oxidation of benzyl alcohol by pyridinium dichromate in acetonitrile. Using the paralmeta ratio of substituent effects for mechanism elucidation

Kabilan,Girija,Reis, Joao Carlos R.,Segurado, Manuel A.P.,De Oliveira, Jaime D. Gomes

, p. 1151 - 1157 (2002)

Industrial synthesis method of o-aldehyde phenyl fatty acid

-

Paragraph 0074; 0076; 0077; 0083; 0085; 0086; 0088; 0090, (2020/01/08)

Synthesis method of O-formyl benzoic acid

-

Paragraph 0009 0011-0012, (2019/12/25)

Synthesis of chiral isoindolinones via asymmetric propargylation/lactamization cascade

Meng, Jiao-Long,Jiao, Tang-Qian,Chen, Ya-Heng,Fu, Rui,Zhang, Shu-Sheng,Zhao, Qian,Feng, Chen-Guo,Lin, Guo-Qiang

supporting information, p. 1564 - 1567 (2018/03/23)

119-67-5 Process route

119-67-5 Upstream products

119-67-5 Downstream products

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