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    2. Organic Intermediates: Pharmaceutical Intermediates

      Home - Products List - Organic Intermediates: Pharmaceutical Intermediates

      3-Methoxybenzoic acid

      • Product Name: 3-Methoxybenzoic acid
      • CAS: 586-38-9
      • Purity:
      • Appearance: white to light yellow crystal powder

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      Inquiry

      Factory supply good quality 3-Methoxybenzoic acid 586-38-9 with stock

      • Molecular Formula:C8H8O3
      • Molecular Weight:152.15
      • Appearance/Colour:white to light yellow crystal powder 
      • Vapor Pressure:0.000303mmHg at 25°C 
      • Melting Point:105-107 °C(lit.) 
      • Refractive Index:1.4945 (estimate) 
      • Boiling Point:308 °C at 760 mmHg 
      • PKA:4.10(at 25℃) 
      • Flash Point:123.3 °C 
      • PSA:46.53000 
      • Density:1.207 g/cm3 
      • LogP:1.39340 

      3-Methoxybenzoic acid(Cas 586-38-9) Usage

      Safety Profile

      Poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating fumes.

      Purification Methods

      Crystallise m-anisic acid from H2O (m 109o, 110.5o) or EtOH/water. The S-benzylisothiuronium salt has m 176o (from EtOH). [Beilstein 10 II 80, 10 III 244, 10 IV 316.]

      General Description

      3-Methoxybenzoic acid is an important intermediate in the synthesis of natural products.

      InChI:InChI=1/C8H8O3/c1-11-7-4-2-3-6(5-7)8(9)10/h2-5H,1H3,(H,9,10)/p-1

      586-38-9 Relevant articles

      Mechanochemical Grignard Reactions with Gaseous CO2 and Sodium Methyl Carbonate**

      Pfennig, Victoria S.,Villella, Romina C.,Nikodemus, Julia,Bolm, Carsten

      supporting information, (2022/01/22)

      A one-pot, three-step protocol for the p...

      Aerobic oxidation of aldehydes to carboxylic acids catalyzed by recyclable ag/c3 n4 catalyst

      Wu, Chaolong,Yao, Xiaoquan,Yu, Min,Zhou, Li,Zhu, Li

      , p. 167 - 175 (2021/03/19)

      The oxidation of aldehydes is an efficie...

      One-Pot Direct Oxidation of Primary Amines to Carboxylic Acids through Tandem ortho-Naphthoquinone-Catalyzed and TBHP-Promoted Oxidation Sequence

      Kim, Hun Young,Oh, Kyungsoo,Si, Tengda

      supporting information, p. 18150 - 18155 (2021/12/09)

      Biomimetic oxidation of primary amines t...

      Selectively Upgrading Lignin Derivatives to Carboxylates through Electrochemical Oxidative C(OH)?C Bond Cleavage by a Mn-Doped Cobalt Oxyhydroxide Catalyst

      Zhou, Hua,Li, Zhenhua,Xu, Si-Min,Lu, Lilin,Xu, Ming,Ji, Kaiyue,Ge, Ruixiang,Yan, Yifan,Ma, Lina,Kong, Xianggui,Zheng, Lirong,Duan, Haohong

      supporting information, p. 8976 - 8982 (2021/03/16)

      Oxidative cleavage of C(OH)?C bonds to a...

      586-38-9 Process route

      1-(3-methoxyphenyl)-3-(4-methoxyphenyl)propane-1,3-dione
      252965-04-1

      1-(3-methoxyphenyl)-3-(4-methoxyphenyl)propane-1,3-dione

      furan-2,3,5(4H)-trione pyridine (1:1)

      furan-2,3,5(4H)-trione pyridine (1:1)

      3-Methoxybenzoic acid
      586-38-9

      3-Methoxybenzoic acid

      4-methoxybenzoic acid
      100-09-4

      4-methoxybenzoic acid

      Conditions
      Conditions Yield
      Das erhaltene Gemisch enthaelt 21-24prozent Anissaeure;
      carbon monoxide
      201230-82-2

      carbon monoxide

      methoxybenzene
      100-66-3

      methoxybenzene

      3-Methoxybenzoic acid
      586-38-9

      3-Methoxybenzoic acid

      4-methoxybenzoic acid
      100-09-4

      4-methoxybenzoic acid

      Conditions
      Conditions Yield
      With palladium diacetate; dipotassium peroxodisulfate; In trifluoroacetic acid; for 20h; Yield given; Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

      586-38-9 Upstream products

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        methanol

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        3-aminophthalic acid

      586-38-9 Downstream products

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        313402-19-6

        3-[4-(3-methoxy-benzoylamino)-phenyl]-coumarin

      • 94611-94-6
        94611-94-6

        3-methoxybenzoic acid anhydride

      • 1527-89-5
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        3-methoxybenzonitrile

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        75731-44-1

        4,3'-dimethoxybenzophenone

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